BETTER SCIENCE

Today in: https://forbetterscience.com/2020/03/26/chloroquine-genius-didier-raoult-to-save-the-world-from-covid-19/?unapproved=72782&moderation-hash=f61fb4b16ba1be2ed83be31c2cfad1bd#comment-72782 my comment

Dr. Dena Grayson @DrDenaGrayson

🛑Hydroxychloroquine (plaquenil) can prolong the QT interval (heart rhythm) and can cause a FATAL arrhythmia. Azithromycin can also prolong the QT interval, so use of these 2 drugs together should ONLY be done under the supervision of a doctor.

I have a question:  Dr. Dena, would she prescribe topical steroids to her patients, knowing that topical steroids cause more adverse reactions than any other existing medications. Here is the partial list:

·        Common side effects reported with topical steroids include:

·        Easy bruising and tearing of the skin.

·        Enlarged blood vessels (telangiectasia)

·        Folliculitis (inflammation of the hair follicles) and miliaria (sweat rash): ointments.

·        Increased hair thickness and length in the area of application (hypertrichosis)

·        Skin thinning.

Besides:

My own mother carried this https://www.pharmaceutical-journal.com/news-and-analysis/diuretic-reduces-skin-atrophy-associated-with-corticosteroid-creams/20068200.article?firstPass=false  wound and suffered from it from her age of 32 until her death at the age of 81.  I am diabetic because of the side effects caused by topical steroids this side effect is not presented on this partial list.

Where:

The side effects caused by hydroxychloroquine are minimal. She and other pundits for their only known reason are playing the crooked psychological tricks with the public by a simple psychological game of fear, by taking only one part out of the context of the description of adverse reactions caused by hydroxychloroquine.

The truth of the meter is:

Mechanism of action described by USP reads as: Hydroxychloroquine increases lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells (PDCs). Toll-like receptor 9 (TLR 9), which recognizes DNA-containing immune complexes, leads to the production of interferon and causes the dendritic cells to mature and present antigen to T cells. Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process. In 2003, a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor (TLR) 9 family receptors.

The short terms side effects of hydroxychloroquine in comparison with other dangerous drugs such as one already mentioned are minimal. Again from the USP:

The most common adverse effects are mild nausea and occasional stomach cramps with mild diarrhea. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued.

The only problem would be if the medication is used for other treatments rather than malaria and viral diseases such as rheumatic arthritis, lupus and so on, that is because of prolonged usage and they are again as described by same sours:

For the prolonged treatment of lupus or rheumatoid arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, the excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. Hydroxychloroquine can worsen existing cases of both psoriasis and porphyria.

Many in the field of medical professions today are asking themselves why this profession is not trustworthy anymore.

Don't ask me, my own experience taught me а lesson, not to trust them. Yes if I am in the acute stage caused by the COVID 19, my physician would proscribe me hydroxychloroquine even if I need to fight to get it.   

                                          

Best regards,

Mike Boyicha

______________

Again, the adverse reaction of azithromycin is minimal comparing to other dangerous drugs.

Most common adverse effects are diarrhea (5%), nausea (3%), abdominal pain (3%), and vomiting. Fewer than 1% of people stop taking the drug due to side effects. Nervousness, skin reactions, and anaphylaxis have been reported.^[29] Clostridium difficile infection has been reported with use of azithromycin.^[3] Azithromycin does not affect the efficacy of birth control unlike some other antibiotics such as rifampin. Hearing loss has been reported.^[30]

Occasionally, people have developed cholestatic hepatitis or delirium. Accidental intravenous overdose in an infant caused severe heart block, resulting in residual encephalopathy.^[31][32]

In 2013 the FDA issued a warning that azithromycin "can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart rhythm." The FDA noted in the warning a 2012 study that found the drug may increase the risk of death, especially in those with heart problems, compared with those on other antibiotics such as amoxicillin or no antibiotic. The warning indicated people with preexisting conditions are at particular risk, such as those with QT interval prolongation, low blood levels of potassium or magnesium, a slower than normal heart rate, or those who use certain drugs to treat abnormal heart rhythms